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  • npm lifecycle scriptsscripts field in package.jsonNode.js
  • setup.py arbitrary code executionsetup.py in source distributions (sdist)Python
  • NODE_OPTIONS preload injectionNODE_OPTIONS environment variable, CLI flags, or .env files loaded via --env-fileNode.js
  • .pth file import execution*.pth files on sys.path (commonly site-packages)Python
  • binding.gyp / node-gyp native compilationbinding.gyp file in the package rootNode.js
  • Corepack (packageManager field)"packageManager" field in package.json, COREPACK_HOME cache directoryNode.js
  • .npmrc registry manipulation.npmrc file (project, user, or global)Node.js
  • overrides / resolutions dependency swapoverrides (npm) or resolutions (Yarn) field in package.jsonNode.js
  • pnpm hooks (pnpmfile.cjs).pnpmfile.cjs in the project rootNode.js
  • .yarnrc.yml plugins and registry.yarnrc.yml in the project rootNode.js
  • pyproject.toml build backendspyproject.toml [build-system] tablePython
  • sitecustomize / usercustomize auto-importsitecustomize.py / usercustomize.py on sys.path (usually site-packages)Python
  • .node native addon loading.node files in node_modules/ (typically under build/Release/ or prebuilds/)Node.js
  • Yarn Plug'n'Play (.pnp.cjs).pnp.cjs in the project rootNode.js
  • __init__.py execution on import__init__.py in any package directory on sys.pathPython
  • .pyc bytecode cache poisoning.pyc files in __pycache__/ directories alongside source modulesPython
  • PYTHONPATH / PYTHONHOME module shadowingPYTHONPATH / PYTHONHOME environment variablesPython
  • npx / npm exec remote executionnpx, npm exec, npm create / npm init (initializer flows)Node.js
  • conftest.py auto-loading (pytest)conftest.py files in any directory pytest traversesPython
  • NODE_PATH environment variableNODE_PATH environment variableNode.js
  • "imports" field (subpath imports)imports field in package.jsonNode.js
  • require.extensions / Module._extensionsrequire.extensions / Module._extensions in any loaded moduleNode.js
  • .egg files and EGG-INFO scripts.egg files in site-packages (registered via easy-install.pth)Python
  • Zip imports (zipimport).zip / .pyz files on sys.path, or passed directly to the interpreterPython
  • PYTHONSTARTUP environment variablePYTHONSTARTUP environment variablePython
  • node_modules/.hooks/ directorynode_modules/.hooks/ directoryNode.js
Python
Interactive REPL/Environment variable

PYTHONSTARTUP environment variable

After interpreter startup, before the REPL prompt appears (interactive mode only)

Lives in
PYTHONSTARTUP environment variable
Attacker needs
Environment control
Lifecycle
Install
Startup
your code
Module load
Runtime
REPL

Runs only in interactive sessions, so it targets developers.

How it runs

The PYTHONSTARTUP env var points to a file that runs when the interactive REPL starts. It does not run when you execute a script. Only the REPL triggers it.

export PYTHONSTARTUP=/tmp/script.py
python   # runs /tmp/script.py before the prompt appears

That limit makes it less useful against servers, but it suits attacks on developers. If you can write to someone's shell profile or .env file, your code runs first every time they open a Python shell to debug something.

Defend

Treat shell profiles and .env files as code; unset PYTHONSTARTUP in shared/CI shells; review dotfiles for unexpected values.